Endocrine Abstracts

Aim: To study the morphofunctional state of the myocardium in young people with diabetes mellitus 1 using magnetic resonance imaging (MRI) technology.Material and methods: 38 patients (14 men, 24 women), aged 18–36 years old, with an experience of type 1 diabetes from 5 to 16 years old were underwent contrastive mri of the heart. The exclusion criteria were: pronounced electrolyte disorders in the blood, dysproteinemia, chronic liver and kidney fail...

Aim: To study the distribution of epicardial fat in young people with type 1 diabetes mellitus using magnetic resonance imaging (MRI) technologies.Material and Methods: 60 patients (29 men, 31 women), aged 18 to 36 years old, with an experience of type 1 diabetes from 5 to 16 years old were underwent contrastive cardio MRI. Measurements of epicardial fat (EF) were carried out on basal (B), medium (M), apical (A) segments of the left (LV) and right ventri...

Introduction: Regardless of improvements in MRI, up to 20% of ACTH-secreting pituitary tumors are only identified at surgical exploration. The objective was to estimate whether there is any difference in blood vessels and the subsequent ability to uptake contrast agent in visualized micro-adenomas as compared to non-visualized on MRI ACTH-secreting pituitary tumors.Materials and methods: Retrospective evaluation of ACTH-positive pituitary tumors from pat...

A 27-year-old male patient during past 10 years noted a gradual change in his appearance, but began to seek a medical attention only 1.5 years ago due to reduced vision. Hormonal tests from March 2013 revealed marked elevation of GH to 106 mIU/ln (ref. values <20), and IGF1 to 567 ng/ml (121–336), decrease in testosterone levels to 1.91 ng/ml (3–12), with cortisol, LH, FSH, PRL, TSH values within the reference range; MRI of the brain showed a 4×7 mm adenoma ...

According to previous research microRNA (miR) are expressed differently in corticotropinoma and ACTH-secreting neuroendocrine tumors. MiR are released into circulation by several mechanisms and considered to be promising biomarkers.Objective: To evaluate whether preselected miR are differently expressed in plasma samples of patients with ACTH-dependent Cushing’s syndrome (CS).Materials and methods: The blood samples were colle...

Cardiovascular complications including arrhythmias and cardiac conduction disorders (ACCDs) are leading risk factors for high mortality rate in acromegaly. ACCDs are the main cause of sudden cardiac death in patients with acromegaly. These disorders are detected in up to 40% of patients. Different pathogenetic mechanisms contribute to the development of concentric biventricular myocardium hypertrophy which leads to electrophysiological myocardium feature changes. The goal of t...

Introduction: A growth hormone-secreting pituitary adenoma (GH-PA) increases the risk of complications and death. It’s management is determined by MRI data and decrease of insulin-like growth factor-1 (IGF-1) during the octreotide suppression test (OST). Currently, there is evidence that MRI-T2-hypointensive somatotropinoma and high expression of somatostatin receptors type 2 (SSTR2) according to immunohistochemical analysis (IHC) predict high efficacy of somatostatin ana...